In the midst of the cold war, the CIA's finest and most fatal female agent, Diana Riley, vanishes. Kidnapped by the KGB and taken to the backcountry of North Carolina, she and her team of unsavory partners are forced to undergo illegal experimentation.

But, when the experiments leave them horribly deformed and unable to reenter society without someone crying monster, the previously glamorous and high-maintenance spies must escape KGB captivity and avoid recapture at the hands of Nikola, a ruthless KGB agent with an intense and well-justified grudge against her former flame.