Seattle is under siege. An ancient ceremony known as "wolf manoth," in which human hunters kill as many canidae as possible, has been revived.

The hunters have arrived in force, focusing on the Pacific Northwest due to its high wolf population. Ariadne Willow, alerted to the danger by her mother, goes undercover with a group of hunters in an effort to minimize the damage. Unfortunately the hunters have a new weapon, a drug that brings out the feral side of any canidae exposed to it.

With her safety and sanity both at risk, Ari is forced to trust a friend turned enemy in order to stay alive. Meanwhile, Dale is cut off from her friend and partner and faces the wrath of drugged canidae and hunters who are eager to make an example of a human who has been consorting with a wolf. Chased through the city and forced to take refuge wherever she can get it, Dale receives help from unexpected corners.

Separated by circumstance and under attack from threats both human and wolf, Ari and Dale must do everything in their power to keep the body count down while also staying alive long enough to find each other again.