It begins with a bus crash. Maggie is a funeral director from Indiana who lives a double life. Bug is a ten-year-old boy in the Pennsylvania foster care system who is sent to live with an aunt he doesn't know. Jimmy is a former paramedic and prescription drug addict on his way to meet a woman he met online who thinks he's a successful doctor. Helen is a Chicago insurance investigator who is leaving her marriage in search of the woman she wants to be. Four strangers, all traveling to Boston in search of better lives, are tied together in ways they don't even realize. Each are trying to fill the void of what's missing in their lives. Sometimes it takes a tragedy to overcome all that we lack.